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Recent Clinical Research on Natural Products

Global Health

Null et al. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya: a cluster-randomised controlled trial. Lancet Glob Health. 2018 Mar;6(3):e316-e329

Luby et al. Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Bangladesh: a cluster randomised controlled trial. Lancet Glob Health 2018, Mar;6(3): e302-e315

In 2 independent studies funded by the Bill & Melinda Gates Foundation, nutritional supplementation was more impactful on child growth than sanitation and handwashing programs.

Gucwa et al. Investigation of the Antifungal Activity and Mode of Action of Thymus vulgaris, Citrus limonum, Pelargonium graveolens, Cinnamomum cassia, Ocimum basilicum, and Eugenia caryophyllus Essential Oils. Molecules. 2018 May 8;23(5). pii: E1116. doi: 10.3390/molecules23051116.

Parvizi  et al. Efficacy of cryotherapy plus topical Juniperus excelsa cream versus cryotherapy plus placebo in the treatment of Old World cutaneous leishmaniasis: A triple-blind randomized controlled clinical trial. PLoS Negl Trop Dis. 2017 Oct 5;11(10):e0005957.

General Nutrition

Johns and Oppenheimer. Was there ever really a “sugar conspiracy”? Science, February 16, 2018;747-750

Buyken et al. Dietary carbohydrates: a review of international recommendations and the methods used to derive them. Eur J Clin Nutr. 2018 Apr 25. doi: 10.1038/s41430-017-0035-4.

Antonio et al. High protein consumption in trained women: bad to the bone? J Int Soc Sports Nutr. 2018 Jan 31;15:6.

Uemura et al. Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men. Scientific Reports 2018 8:9667


Lima-Soares, Fernanda, et al. "HMB Supplementation: Clinical and Performance-Related Effects and Mechanisms of Action." Sustained Energy for Enhanced Human Functions and Activity. 2018. 363-381.

Srivastava et al. Effect of Alpinia galanga on Mental Alertness and Sustained Attention With or Without Caffeine: A Randomized Placebo-Controlled Study. Journal of the American College of Nutrition 2017. 36:8, 631-639, DOI: 10.1080/07315724.2017.1342576

Hernández‐Santana et al. A Rhodiola Rosea Root Extract Protects Skeletal Muscle Cells Against Chemically Induced Oxidative Stress by Modulating Heat Shock Protein 70 (HSP70) Expression. Phytother. Res. 2017, 28: 623-628. doi:10.1002/ptr.5046

Scholl C, Lepper A, Lehr T, Hanke N, Schneider KL, Brockmöller J, et al. (2018) Population nutrikinetics of green tea extract. PLoS ONE 13(2): e0193074.

Sadowska-Krępa et al.  Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men. Nutrients. 2017 Jul 26;9(8). pii: E803.

Buchwald-Werner et al.  Effects of lemon verbena extract supplementation on muscle strength and recovery after exhaustive exercise: a randomized, placebo-controlled trial.  BMC Complement Altern Med. 2018 Jan 22;18(1):22.

Juszkiewicz et al.  An attempt to induce an immunomodulatory effect in rowers with spirulina extract. J Int Soc Sports Nutr. 2018 Feb 20;15:9

Pons  et al. Calorie restriction regime enhances physical performance of trained athletes. J Int Soc Sports Nutr. 2018 Mar 9;15:12.

Jonvik et al. Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes. Eur J Sport Sci. 2018 May;18(4):524-533.

Healthy Aging

Hughes et al. Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. The American Journal of Clinical Nutrition, Volume 104, Issue 2, 1 August 2016, Pages 406–414,

Herrlinger et al. Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment. ]. J Altern Complement Med. 2018 Jan;24(1):37-47.

Paller et al. Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial. Clin Cancer Res. 2018 Jan 15;24(2):306-315. doi: 10.1158/1078-0432.CCR-17-1100.

Digestive Health

Varnosfaderani et al. Efficacy and safety of amla (Phyllanthus emblica L.) in non-erosive reflux disease: a double-blind, randomized, placebo-controlled clinical trial. J Integr Med. 2018 Mar;16(2):126-131. doi: 10.1016/j.joim.2018.02.008.


Rezazadeh et al. Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms. Phytother Res. 2018 Jan;32(1):84-93. doi: 10.1002/ptr.5951.

Bae et al. Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway.  Am J Chin Med. 2018;46(3):617-632. doi: 10.1142/S0192415X18500325.

Pediatric Health

Abbasi et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complement Ther Med. 2017 Dec;35:85-91.

Lee et al.  Effects of Astragalus Extract Mixture HT042 on Height Growth in Children with Mild Short Stature: A Multicenter Randomized Controlled Trial. Phytother Res. 2018 Jan;32(1):49-57. doi: 10.1002/ptr.5886.

Cremonte et al.  The Effect of Experimental Supplementation with the Klamath Algae Extract Klamin on Attention-Deficit/Hyperactivity Disorder. J Med Food. 2017 Dec;20(12):1233-1239.

Safety & Quality

Andrews et al.  Analytical ingredient content and variability of adult multivitamin/mineral products: national estimates for the Dietary Supplement Ingredient Database. The American Journal of Clinical Nutrition, Volume 105, Issue 2, 1 February 2017, Pages 526–539,

Newman and Cragg, Natural Products as Sources of New Drugs from 1981 to 2014. J. Nat. Prod., 2016, 79 (3), pp 629–661 DOI: 10.1021/acs.jnatprod.5b01055

Ranasinghe et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med. 2017 Dec 28;17(1):550. doi: 10.1186/s12906-017-2067-7.