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Experienced healthy food and dietary supplement consultants
helping you design and deliver world-class products.

R&D and Innovation News:

  • Recently Published: First 7 Steps to Dietary Supplement Product Design Success
  • Can a Meal Replacement Drink Improve Body Weight and Nutrient Status in Healthy People? Ebersole to present results of pilot human study on Soylent 2.0 at 2018 International Society of Sports Nutrition Annual Meeting in Clearwater, Florida
  • NaturPro Reviews Low-Carb Diet Program.  We recently reviewed pilot clinical data on a diet program that combines calorie restriction with low-carb in a flexible diet plan.
  • NaturPro Completes Study on Transdermal Athletic Performance Product. This randomized, placebo controlled pilot study found that a transdermal patch with vitamins and herbs may improve subjective scores of mood and energy.  
  • NaturPro Sponsors Development of Dietary Endocannabinoid Ligands for Pain Relief.  A new technology based on anandamide ligands produced by the body has the potential to replace commonly used NSAIDS for pain and inflammation.

Product Quality & Safety Update:


NaturPro Scientific are Experts Supporting Innovation, Production and Compliance

for Natural Products that Support Human Health

Follow on Twitter @NaturalBlake
or Instagram @NaturPro




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What's New

We serve as an advocate for our clients' R&D, quality assurance and development of natural products that support the health of the world.


Recent Milestones:


  • Supported Development of 35 New Natural Products
  • 19 Improvements to Formulas or Production Processes
  • 50+ Product/Business Opportunities Evaluated
  • 100+ Product Labels Reviewed and Optimized
  • 20+ GMP (Good Manufacturing Practices) and Supplier Audits
  • 9 Research Trials Planned to Support Clinical Efficacy and Safety
  • 50+ Substantiated Product Claims
  • 100+ Materials Verified with Valid Test Methods
  • 200+ Samples Tested for Adherence to Truth-in-Labeling
  • 30+ Materials Testing Issues Resolved
  • 14 Assessments of Regulatory Status
  • 5 Responses to Regulatory Actions
  • 1 Analytical Method validation and AOAC First Action Official Method
  • 4 Research Studies Published in Refereed Journals/Conferences

New Clinical Research on Natural Products




A randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of a novel green-lipped mussel extract -BioLex® -for managing pain in moderate to severe osteoarthritis of the hip and knee.

Stebbings S, Gray A, Schneiders AG, Sansom A.

BMC Complement Altern Med. 2017 Aug 22;17(1):416. doi: 10.1186/s12906-017-1907-9.


Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial.

Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, Christensen LP, Jeppesen PB.

Am J Clin Nutr. 2017 Sep;106(3):909-920. doi: 10.3945/ajcn.117.153353. Epub 2017 Aug 2.


Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial.

Cho YG, Jung JH, Kang JH, Kwon JS, Yu SP, Baik TG.

BMC Complement Altern Med. 2017 Jul 28;17(1):375. doi: 10.1186/s12906-017-1871-4.


Novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.

Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M.

Complement Ther Med. 2017 Aug;33:58-64. doi: 10.1016/j.ctim.2017.06.001.


Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study.

Steels E, Steele ML, Harold M, Coulson S.

Phytother Res. 2017 Sep;31(9):1316-1322. doi: 10.1002/ptr.5856. Epub 2017 Jul 14.


Effect of green tea extract supplementation on glycogen replenishment in exercised human skeletal muscle.

Tsai TW, Chang CC, Liao SF, Liao YH, Hou CW, Tsao JP, Cheng IS.

Br J Nutr. 2017 May;117(10):1343-1350. doi: 10.1017/S0007114517001374.

Impact of mulberry leaf extract on type 2 diabetes (Mul-DM): A randomized, placebo-controlled pilot study.

Riche DM, Riche KD, East HE, Barrett EK, May WL.

Complement Ther Med. 2017 Jun;32:105-108. doi: 10.1016/j.ctim.2017.04.006. Epub 2017 Apr 27.


Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.

Lambert MNT, Thorup AC, Hansen ESS, Jeppesen PB.

PLoS One. 2017 Jun 7;12(6):e0176590.


A Randomized, Double-blind, Placebo-controlled Clinical Trial Examining the Effects of Green Tea Extract on Systemic Lupus Erythematosus Disease Activity and Quality of Life.

Shamekhi Z, Amani R, Habibagahi Z, Namjoyan F, Ghadiri A, Saki Malehi A.

Phytother Res. 2017 Jul;31(7):1063-1071. doi: 10.1002/ptr.5827. Epub 2017 Jun 6.


The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial.

Indrawati L, Ascobat P, Bela B, Abdullah M, Surono IS.

Asia Pac J Clin Nutr. 2017;26(4):606-612. doi: 10.6133/apjcn.062016.02.


Potato protease inhibitor II suppresses postprandial appetite in healthy women: a randomized double-blind placebo-controlled trial.

Zhu Y, Lasrado JA, Hu J.

Food Funct. 2017 May 24;8(5):1988-1993. doi: 10.1039/c6fo01803c.


The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial.

Kheiri A, Amini S, Javidan AN, Saghafi MM, Khorasani G.

BMC Complement Altern Med. 2017 May 8;17(1):253. doi: 10.1186/s12906-017-1741-0.


Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study.

Bodemer C, Guillet G, Cambazard F, Boralevi F, Ballarini S, Milliet C, Bertuccio P, La Vecchia C, Bach JF, de Prost Y.

PLoS One. 2017 Mar 23;12(3):e0161555


Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study.

Lown M, Fuller R, Lightowler H, Fraser A, Gallagher A, Stuart B, Byrne C, Lewith G.

PLoS One. 2017 Feb 22;12(2):e0172239. doi: 10.1371/journal.pone.0172239. eCollection 2017.


Assessment of efficacy and safety of the herbal medicinal product BNO 1016 in chronic rhinosinusitis.

Palm J, Steiner I, Abramov-Sommariva D, Ammendola A, Mitzenheim S, Steindl H, Wonnemann M, Bachert C.

Rhinology. 2017 Jun 1;55(2):142-151. doi: 10.4193/Rhin16.103.


Acute improvement of endothelial functions after oral ingestion of isohumulones, bitter components of beer.

Tomita J, Mochizuki S, Fujimoto S, Kashihara N, Akasaka T, Tanimoto M, Yoshida K.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):740-745. doi:


Effect of porcine placental extract on the mild menopausal symptoms of climacteric women.

Kitanohara M, Yamamoto T, Masunaga S, Ohishi M, Komatsu Y, Nagase M.

Climacteric. 2017 Apr;20(2):144-150. doi: 10.1080/13697137.2017.1279140.


Food-specific sublingual immunotherapy is well tolerated and safe in healthy dogs: a blind, randomized, placebo-controlled study.

Maina E, Pelst M, Hesta M, Cox E.

BMC Vet Res. 2017 Jan 18;13(1):25. doi: 10.1186/s12917-017-0947-1.


Dietary Wolfberry Extract Modifies Oxidative Stress by Controlling the Expression of Inflammatory mRNAs in Overweight and Hypercholesterolemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lee YJ, Ahn Y, Kwon O, Lee MY, Lee CH, Lee S, Park T, Kwon SW, Kim JY.

J Agric Food Chem. 2017 Jan 18;65(2):309-316. doi: 10.1021/acs.jafc.6b04701.


Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women.

Nhung BT, Tuyen LD, Linh VA, Anh ND, Nga TT, Thuc VT, Yui K, Ito Y, Nakashima Y, Yamamoto S.

J Nutr Sci Vitaminol (Tokyo). 2016;62(5):295-302.


Human Intervention Study to Assess the Effects of Supplementation with Olive Leaf Extract on Peripheral Blood Mononuclear Cell Gene Expression.

Boss A, Kao CH, Murray PM, Marlow G, Barnett MP, Ferguson LR.

Int J Mol Sci. 2016 Dec 2;17(12). pii: E2019.


Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial.

Mao JJ, Xie SX, Keefe JR, Soeller I, Li QS, Amsterdam JD.

Phytomedicine. 2016 Dec 15;23(14):1735-1742. doi: 10.1016/j.phymed.2016.10.012. Epub 2016 Oct 24.


Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder.

Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD.

Phytomedicine. 2016 Dec 15;23(14):1699-1705. doi: 10.1016/j.phymed.2016.10.013.

Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders.

Kerns ML, Guss L, Fahey J, Cohen B, Hakim JM, Sung S, Lu RG, Coulombe PA.

J Am Acad Dermatol. 2017 Mar;76(3):449-453.e1. doi: 10.1016/j.jaad.2016.10.009.


Evaluation of the Effects of Cucumis sativus Seed Extract on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

Soltani R, Hashemi M, Farazmand A, Asghari G, Heshmat-Ghahdarijani K, Kharazmkia A, Ghanadian SM.

J Food Sci. 2017 Jan;82(1):214-218. doi: 10.1111/1750-3841.13569.

Beneficial Effects of Pterocarpan-High Soybean Leaf Extract on Metabolic Syndrome in Overweight and Obese Korean Subjects: Randomized Controlled Trial.

Ryu R, Jeong TS, Kim YJ, Choi JY, Cho SJ, Kwon EY, Jung UJ, Ji HS, Shin DH, Choi MS.

Nutrients. 2016 Nov 18;8(11). pii: E734.


Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.

Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S; Broccoli Sprout Extract Trial Research Group.

PLoS One. 2016 Nov 10;11(11):e0163716. doi: 10.1371/journal.pone.0163716. eCollection 2016.


Novel bioactive from Lactobacillus brevis DSM17250 to stimulate the growth of Staphylococcus epidermidis: a pilot study.

Holz C, Benning J, Schaudt M, Heilmann A, Schultchen J, Goelling D, Lang C.

Benef Microbes. 2017 Feb 7;8(1):121-131. doi: 10.3920/BM2016.0073. Epub 2016 Nov 8.


A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double-Blind, Placebo-Controlled Study.

Shamshad Begum S, Jayalakshmi HK, Vidyavathi HG, Gopakumar G, Abin I, Balu M, Geetha K, Suresha SV, Vasundhara M, Krishnakumar IM.

Phytother Res. 2016 Nov;30(11):1775-1784. doi: 10.1002/ptr.5680. Epub 2016 Jul 13.


Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial.

Samavat H, Newman AR, Wang R, Yuan JM, Wu AH, Kurzer MS.

Am J Clin Nutr. 2016 Dec;104(6):1671-1682. Epub 2016 Nov 2.


An open-label six-month extension study to investigate the safety and efficacy of an extract of Artemisia annua for managing pain, stiffness and functional limitation associated with osteoarthritis of the hip and knee.

Hunt S, Stebbings S, McNamara D.

N Z Med J. 2016 Oct 28;129(1444):97-102.


Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers.

Jeykodi S, Deshpande J, Juturu V.

J Diabetes Res. 2016;2016:7971831.


Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial.

Valls RM, Llauradó E, Fernández-Castillejo S, Puiggrós F, Solà R, Arola L, Pedret A.

Phytomedicine. 2016 Nov 15;23(12):1451-1461. doi: 10.1016/j.phymed.2016.08.007.


A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms.

Park JY, Kim KH.

Climacteric. 2016 Dec;19(6):574-580. Epub 2016 Oct 20.


Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial.

Srivastava S, Saksena AK, Khattri S, Kumar S, Dagur RS.

Inflammopharmacology. 2016 Dec;24(6):377-388. Epub 2016 Oct 19.


Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lee N, Lee SH, Yoo HR, Yoo HS.

J Altern Complement Med. 2016 Nov;22(11):859-864. Epub 2016 Oct 18.


The Effect of Green Tea and Sour Tea (Hibiscus sabdariffa L.) Supplementation on Oxidative Stress and Muscle Damage in Athletes.

Hadi A, Pourmasoumi M, Kafeshani M, Karimian J, Maracy MR, Entezari MH.

J Diet Suppl. 2017 May 4;14(3):346-357. Epub 2016 Oct 13.


Jasmine rice panicle: A safe and efficient natural ingredient for skin aging treatments.

Kanlayavattanakul M, Lourith N, Chaikul P.

J Ethnopharmacol. 2016 Dec 4;193:607-616. doi: 10.1016/j.jep.2016.10.013.


Specific expectancies are associated with symptomatic outcomes and side effect burden in a trial of chamomile extract for generalized anxiety disorder.

Keefe JR, Amsterdam J, Li QS, Soeller I, DeRubeis R, Mao JJ.

J Psychiatr Res. 2017 Jan;84:90-97. doi: 10.1016/j.jpsychires.2016.09.029. Epub 2016 Sep 30.


Differential vascular reactivity responses acutely following ingestion of a nitrate rich red spinach extract.

Haun CT, Kephart WC, Holland AM, Mobley CB, McCloskey AE, Shake JJ, Pascoe DD, Roberts MD, Martin JS.

Eur J Appl Physiol. 2016 Dec;116(11-12):2267-2279. Epub 2016 Sep 30.


Effects of pomegranate extract on blood flow and vessel diameter after high-intensity exercise in young, healthy adults.

Roelofs EJ, Smith-Ryan AE, Trexler ET, Hirsch KR, Mock MG.

Eur J Sport Sci. 2017 Apr;17(3):317-325. doi: 10.1080/17461391.2016.1230892.


Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan , in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study.

Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E.

Scand J Immunol. 2016 Dec;84(6):323-331.


The effect of Vaccinium uliginosum extract on tablet computer-induced asthenopia: randomized placebo-controlled study.

Park CY, Gu N, Lim CY, Oh JH, Chang M, Kim M, Rhee MY.

BMC Complement Altern Med. 2016 Aug 18;16:296. doi: 10.1186/s12906-016-1283-x.


Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial.

Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, Gholampour B, Mohammadpour AH, Sahebkar A.

Complement Ther Med. 2016 Aug;27:25-9. doi: 10.1016/j.ctim.2016.03.018.


Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals.

Takanari J, Nakahigashi J, Sato A, Waki H, Miyazaki S, Uebaba K, Hisajima T.

J Nutr Sci Vitaminol (Tokyo). 2016;62(3):198-205.


Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study.

Gilardini L, Pasqualinotto L, Di Pierro F, Risso P, Invitti C.

BMC Complement Altern Med. 2016 Jul 22;16:233.


Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men.

Joy JM, Vogel RM, Moon JR, Falcone PH, Mosman MM, Pietrzkowski Z, Reyes T, Kim MP.

BMC Complement Altern Med. 2016 Jul 18;16:224. doi: 10.1186/s12906-016-1222-x.


Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study.

Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E.

PLoS One. 2016 Jul 14;11(7):e0159288.


Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation.

Jensen GS, Drapeau C, Lenninger M, Benson KF.

J Med Food. 2016 Jul;19(7):645-53. doi: 10.1089/jmf.2015.0143.